TargetNet
P08311
Cathepsin G
Function
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride.
Database Links
| Database | Links |
|---|---|
| UniProt | P08311 |
| PDB | 1AU8, 1CGH, 1KYN, 1T32 |
| BioGrid | 107891 |
| BindingDB | P08311 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2348 |
| PharmGKB | PA27032 |
| KEGG | hsa:1511 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1511 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8773 | 0.0072 |
| Accuracy | 0.7962 | 0.0104 |
| Sensitivity | 0.8556 | 0.0158 |
| Specificity | 0.7282 | 0.0168 |
| BEDROC | 0.9716 | 0.0109 |
| MCC Threshold | 0.608 | N/A |
| MCC | 0.5856 | N/A |
| F-score Threshold | 0.422 | N/A |
| F-score | 0.8146 | N/A |