TargetNet
P08254
Stromelysin-1
Function
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Database Links
| Database | Links |
|---|---|
| UniProt | P08254 |
| PDB | 1B3D, 1B8Y, 1BIW, 1BM6, 1BQO, 1C3I, 1C8T, 1CAQ, 1CIZ, 1CQR, 1D5J, 1D7X, 1D8F, 1D8M, 1G05, 1G49, 1G4K, 1HFS, 1HY7, 1M1W, 1OO9, 1QIA, 1QIC, 1SLM, 1SLN, 1UEA, 1UMS, 1UMT, 1USN, 2D1O, 2JNP, 2JT5, 2JT6, 2SRT, 2USN, 3OHL, 3OHO, 3USN, 4DPE, 4G9L, 4JA1 |
| BioGrid | 110458 |
| BindingDB | P08254 |
| DrugBank | DB00786, DB00641 |
| Guide to PHARMACOLOGY | 1630 |
| PharmGKB | PA30886 |
| KEGG | hsa:4314 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4314 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9581 | 8.8984 × 10-4 |
| Accuracy | 0.9125 | 0.0024 |
| Sensitivity | 0.9316 | 0.0038 |
| Specificity | 0.8899 | 0.0039 |
| BEDROC | 0.9678 | 0.0043 |
| MCC Threshold | 0.468 | N/A |
| MCC | 0.8221 | N/A |
| F-score Threshold | 0.468 | N/A |
| F-score | 0.9201 | N/A |