TargetNet
P08246
Neutrophil elastase
Function
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
Database Links
| Database | Links |
|---|---|
| UniProt | P08246 |
| PDB | 1B0F, 1H1B, 1HNE, 1PPF, 1PPG, 2RG3, 2Z7F, 3Q76, 3Q77 |
| BioGrid | 108306 |
| BindingDB | P08246 |
| DrugBank | DB00058, DB00099, DB00019 |
| Guide to PHARMACOLOGY | 2358 |
| PharmGKB | PA27735 |
| KEGG | hsa:1991 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1991 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9671 | 0.0017 |
| Accuracy | 0.9146 | 0.0041 |
| Sensitivity | 0.9177 | 0.0047 |
| Specificity | 0.9109 | 0.0048 |
| BEDROC | 0.9945 | 0.0013 |
| MCC Threshold | 0.436 | N/A |
| MCC | 0.8369 | N/A |
| F-score Threshold | 0.436 | N/A |
| F-score | 0.9264 | N/A |