TargetNet
P08238
Heat shock protein HSP 90-beta
Function
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
Database Links
| Database | Links |
|---|---|
| UniProt | P08238 |
| PDB | 1QZ2, 1UYM, 3NMQ, 3PRY |
| BioGrid | 109558 |
| BindingDB | P08238 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA29524 |
| KEGG | hsa:3326 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3326 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9564 | 0.0025 |
| Accuracy | 0.8969 | 0.005 |
| Sensitivity | 0.8844 | 0.0059 |
| Specificity | 0.9077 | 0.0075 |
| BEDROC | 0.9924 | 0.0053 |
| MCC Threshold | 0.418 | N/A |
| MCC | 0.8036 | N/A |
| F-score Threshold | 0.418 | N/A |
| F-score | 0.8956 | N/A |