TargetNet
P08235
Mineralocorticoid receptor
Function
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Database Links
| Database | Links |
|---|---|
| UniProt | P08235 |
| PDB | 1Y9R, 1YA3, 2A3I, 2AA2, 2AA5, 2AA6, 2AA7, 2AAX, 2AB2, 2ABI, 2OAX, 3VHU, 3VHV, 3WFF, 3WFG |
| BioGrid | 110451 |
| BindingDB | P08235 |
| DrugBank | DB01134, DB00700, DB00687, DB00421 |
| Guide to PHARMACOLOGY | 626 |
| PharmGKB | PA242 |
| KEGG | hsa:4306 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4306 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9636 | 0.0033 |
| Accuracy | 0.9401 | 0.0052 |
| Sensitivity | 0.9479 | 0.0068 |
| Specificity | 0.9304 | 0.0051 |
| BEDROC | 0.9622 | 0.0123 |
| MCC Threshold | 0.552 | N/A |
| MCC | 0.8945 | N/A |
| F-score Threshold | 0.542 | N/A |
| F-score | 0.9527 | N/A |