TargetNet
P08183
Multidrug resistance protein 1
Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Database Links
| Database | Links |
|---|---|
| UniProt | P08183 |
| PDB | Not available |
| BioGrid | 111262 |
| BindingDB | P08183 |
| DrugBank | DB00171, DB00802, DB01169, DB01072, DB01136, DB01394, DB00091, DB00694, DB00975, DB01196, DB00875, DB00619, DB01167, DB00622, DB01182, DB01103, DB00908, DB00243, DB01045, DB00778, DB01232, DB00675, DB00570 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA267 |
| KEGG | hsa:5243 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5243 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8728 | 0.0055 |
| Accuracy | 0.8093 | 0.0087 |
| Sensitivity | 0.8098 | 0.0114 |
| Specificity | 0.8088 | 0.0094 |
| BEDROC | 0.9655 | 0.0078 |
| MCC Threshold | 0.544 | N/A |
| MCC | 0.6328 | N/A |
| F-score Threshold | 0.456 | N/A |
| F-score | 0.8116 | N/A |