Muscarinic acetylcholine receptor M4
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
Database | Links |
---|---|
UniProt | P08173 |
PDB | Not available |
BioGrid | 107554 |
BindingDB | P08173 |
DrugBank | DB00572, DB00767, DB00785, DB00725, DB01403, DB00340, DB00334, DB00387, DB00420, DB01069, DB00777, DB00372, DB00809 |
Guide to PHARMACOLOGY | 16 |
PharmGKB | PA26485 |
KEGG | hsa:1132 |
BioCyc | Not available |
Entrez Gene (GeneID) | 1132 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9187 | 0.005 |
Accuracy | 0.8583 | 0.0062 |
Sensitivity | 0.8569 | 0.0099 |
Specificity | 0.8597 | 0.0072 |
BEDROC | 0.9873 | 0.008 |
MCC Threshold | 0.528 | N/A |
MCC | 0.728 | N/A |
F-score Threshold | 0.438 | N/A |
F-score | 0.8612 | N/A |