TargetNet
P08172
Muscarinic acetylcholine receptor M2
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
Database Links
| Database | Links |
|---|---|
| UniProt | P08172 |
| PDB | 1LUB, 3UON, 4MQS, 4MQT |
| BioGrid | 107551 |
| BindingDB | P08172 |
| DrugBank | DB00517, DB00572, DB00767, DB00411, DB00785, DB01176, DB01151, DB01231, DB01334, DB01135, DB01148, DB00483, DB00725, DB00424, DB00332, DB01403, DB00340, DB01336, DB01226, DB00334, DB01062, DB00383, DB01085, DB00387, DB00420, DB01069, DB00777, DB00728, DB00372, DB01036, DB00505, DB00508 |
| Guide to PHARMACOLOGY | 14 |
| PharmGKB | PA111 |
| KEGG | hsa:1129 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1129 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9572 | 0.0015 |
| Accuracy | 0.8996 | 0.0039 |
| Sensitivity | 0.8935 | 0.0047 |
| Specificity | 0.9056 | 0.0064 |
| BEDROC | 0.991 | 0.0022 |
| MCC Threshold | 0.594 | N/A |
| MCC | 0.8086 | N/A |
| F-score Threshold | 0.468 | N/A |
| F-score | 0.9008 | N/A |