TargetNet
P07943
Aldose reductase
Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Database Links
| Database | Links |
|---|---|
| UniProt | P07943 |
| PDB | Not available |
| BioGrid | 246382 |
| BindingDB | P07943 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:24192 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24192 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8882 | 0.008 |
| Accuracy | 0.815 | 0.0078 |
| Sensitivity | 0.7996 | 0.0139 |
| Specificity | 0.8282 | 0.0099 |
| BEDROC | 0.9572 | 0.0262 |
| MCC Threshold | 0.544 | N/A |
| MCC | 0.6493 | N/A |
| F-score Threshold | 0.378 | N/A |
| F-score | 0.8065 | N/A |