P07900

Heat shock protein HSP 90-alpha

Function

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Database Links

Database	Links
UniProt	P07900
PDB	1BYQ, 1OSF, 1UY6, 1UY7, 1UY8, 1UY9, 1UYC, 1UYD, 1UYE, 1UYF, 1UYG, 1UYH, 1UYI, 1UYK, 1UYL, 1YC1, 1YC3, 1YC4, 1YER, 1YES, 1YET, 2BSM, 2BT0, 2BUG, 2BYH, 2BYI, 2BZ5, 2C2L, 2CCS, 2CCT, 2CCU, 2CDD, 2FWY, 2FWZ, 2H55, 2JJC, 2K5B, 2QF6, 2QFO, 2QG0, 2QG2, 2UWD, 2VCI, 2VCJ, 2WI1, 2WI2, 2WI3, 2WI4, 2WI5, 2WI6, 2WI7, 2XAB, 2XDK, 2XDL, 2XDS, 2XDU, 2XDX, 2XHR, 2XHT, 2XHX, 2XJG, 2XJJ, 2XJX, 2XK2, 2YE2, 2YE3, 2YE4, 2YE5, 2YE6, 2YE7, 2YE8, 2YE9, 2YEA, 2YEB, 2YEC, 2YED, 2YEE, 2YEF, 2YEG, 2YEH, 2YEI, 2YEJ, 2YI0, 2YI5, 2YI6, 2YI7, 2YJW, 2YJX, 2YK2, 2YK9, 2YKB, 2YKC, 2YKE, 2YKI, 2YKJ, 3B24, 3B25, 3B26, 3B27, 3B28, 3BM9, 3BMY, 3D0B, 3EKO, 3EKR, 3FT5, 3FT8, 3HEK, 3HHU, 3HYY, 3HYZ, 3HZ1, 3HZ5, 3INW, 3INX, 3K97, 3K98, 3K99, 3MNR, 3O0I, 3OW6, 3OWB, 3OWD, 3Q6M, 3Q6N, 3QDD, 3QTF, 3R4M, 3R4N, 3R4O, 3R4P, 3R91, 3R92, 3RKZ, 3RLP, 3RLQ, 3RLR, 3T0H, 3T0Z, 3T10, 3T1K, 3T2S, 3TUH, 3VHA, 3VHC, 3VHD, 3WHA, 4AIF, 4AWO, 4AWP, 4AWQ, 4B7P, 4BQJ, 4EEH, 4EFT, 4EFU, 4EGH, 4EGI, 4EGK, 4FCP, 4FCQ, 4FCR, 4HY6, 4JQL, 4NH7, 4NH8
BioGrid	109552
BindingDB	P07900
DrugBank	DB00615
Guide to PHARMACOLOGY	Not available
PharmGKB	PA29519
KEGG	hsa:3320
BioCyc	Not available
Entrez Gene (GeneID)	3320

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.9142	0.0046
Accuracy	0.8564	0.0089
Sensitivity	0.8343	0.009
Specificity	0.8815	0.0159
BEDROC	0.9991	2.2044 × 10^-4
MCC Threshold	0.532	N/A
MCC	0.7377	N/A
F-score Threshold	0.506	N/A
F-score	0.869	N/A

Downloads

R Model Object

Random Forest model object (.RData)

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Positive Set

SMILES string + affinity value (.tsv)

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TargetNet