TargetNet
P07861
Neprilysin
Function
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Displays UV- inducible elastase activity toward skin preelastic and elastic fibers (By similarity). Involved in the degradation of atrial natriuretic factor (ANF).
Database Links
| Database | Links |
|---|---|
| UniProt | P07861 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P07861 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:24590 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24590 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9866 | 0.0017 |
| Accuracy | 0.9513 | 0.0046 |
| Sensitivity | 0.9543 | 0.0058 |
| Specificity | 0.9488 | 0.0047 |
| BEDROC | 0.9975 | 0.0031 |
| MCC Threshold | 0.368 | N/A |
| MCC | 0.9083 | N/A |
| F-score Threshold | 0.368 | N/A |
| F-score | 0.9512 | N/A |