TargetNet
P07858
Cathepsin B
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
Database Links
| Database | Links |
|---|---|
| UniProt | P07858 |
| PDB | 1CSB, 1GMY, 1HUC, 1PBH, 2IPP, 2PBH, 3AI8, 3CBJ, 3CBK, 3K9M, 3PBH |
| BioGrid | 107888 |
| BindingDB | P07858 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2343 |
| PharmGKB | PA27027 |
| KEGG | hsa:1508 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1508 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8925 | 0.0029 |
| Accuracy | 0.8244 | 0.0057 |
| Sensitivity | 0.8514 | 0.008 |
| Specificity | 0.7917 | 0.0113 |
| BEDROC | 0.9682 | 0.0105 |
| MCC Threshold | 0.526 | N/A |
| MCC | 0.6688 | N/A |
| F-score Threshold | 0.496 | N/A |
| F-score | 0.8526 | N/A |