TargetNet
P07711
Cathepsin L1
Function
Important for the overall degradation of proteins in lysosomes.
Database Links
| Database | Links |
|---|---|
| UniProt | P07711 |
| PDB | 1CJL, 1CS8, 1ICF, 1MHW, 2NQD, 2VHS, 2XU1, 2XU3, 2XU4, 2XU5, 2YJ2, 2YJ8, 2YJ9, 2YJB, 2YJC, 3BC3, 3H89, 3H8B, 3H8C, 3HHA, 3HWN, 3IV2, 3K24, 3KSE, 3OF8, 3OF9, 4AXL, 4AXM |
| BioGrid | 107894 |
| BindingDB | P07711 |
| DrugBank | DB00040 |
| Guide to PHARMACOLOGY | 2351 |
| PharmGKB | PA162382890 |
| KEGG | hsa:1514 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1514 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9031 | 0.004 |
| Accuracy | 0.8413 | 0.0045 |
| Sensitivity | 0.8426 | 0.0076 |
| Specificity | 0.84 | 0.0078 |
| BEDROC | 0.9485 | 0.0091 |
| MCC Threshold | 0.496 | N/A |
| MCC | 0.6912 | N/A |
| F-score Threshold | 0.418 | N/A |
| F-score | 0.8451 | N/A |