TargetNet
P07477
Trypsin-1
Function
Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates.
Database Links
| Database | Links |
|---|---|
| UniProt | P07477 |
| PDB | 1FXY, 1TRN, 2RA3 |
| BioGrid | 111626 |
| BindingDB | P07477 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2397 |
| PharmGKB | PA33828 |
| KEGG | hsa:5644 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5644 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9715 | 0.0013 |
| Accuracy | 0.9277 | 0.003 |
| Sensitivity | 0.943 | 0.0042 |
| Specificity | 0.9093 | 0.0045 |
| BEDROC | 0.9914 | 0.0023 |
| MCC Threshold | 0.502 | N/A |
| MCC | 0.8616 | N/A |
| F-score Threshold | 0.502 | N/A |
| F-score | 0.9375 | N/A |