TargetNet
P07384
Calpain-1 catalytic subunit
Function
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Database Links
| Database | Links |
|---|---|
| UniProt | P07384 |
| PDB | 1ZCM, 2ARY |
| BioGrid | 107273 |
| BindingDB | P07384 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA26057 |
| KEGG | hsa:823 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 823 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9781 | 0.0018 |
| Accuracy | 0.9364 | 0.0034 |
| Sensitivity | 0.9567 | 0.0063 |
| Specificity | 0.919 | 0.0027 |
| BEDROC | 0.9836 | 0.0052 |
| MCC Threshold | 0.45 | N/A |
| MCC | 0.8703 | N/A |
| F-score Threshold | 0.45 | N/A |
| F-score | 0.9312 | N/A |