TargetNet
P07339
Cathepsin D
Function
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Database Links
| Database | Links |
|---|---|
| UniProt | P07339 |
| PDB | 1LYA, 1LYB, 1LYW |
| BioGrid | 107889 |
| BindingDB | P07339 |
| DrugBank | DB00047, DB00046, DB00030, DB00071 |
| Guide to PHARMACOLOGY | 2345 |
| PharmGKB | PA27029 |
| KEGG | hsa:1509 |
| BioCyc | MetaCyc:HS04183-MONOMER |
| Entrez Gene (GeneID) | 1509 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9549 | 0.0021 |
| Accuracy | 0.9036 | 0.004 |
| Sensitivity | 0.9116 | 0.0062 |
| Specificity | 0.8959 | 0.0048 |
| BEDROC | 0.9838 | 0.0029 |
| MCC Threshold | 0.464 | N/A |
| MCC | 0.8186 | N/A |
| F-score Threshold | 0.464 | N/A |
| F-score | 0.9091 | N/A |