TargetNet
P07308
Acyl-CoA desaturase 1
Function
Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.
Database Links
| Database | Links |
|---|---|
| UniProt | P07308 |
| PDB | Not available |
| BioGrid | 251497 |
| BindingDB | P07308 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:246074 |
| BioCyc | MetaCyc:MONOMER-14123 |
| Entrez Gene (GeneID) | 246074 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9543 | 0.0026 |
| Accuracy | 0.9246 | 0.0029 |
| Sensitivity | 0.9516 | 0.0086 |
| Specificity | 0.8986 | 0.0049 |
| BEDROC | 0.9409 | 0.0133 |
| MCC Threshold | 0.538 | N/A |
| MCC | 0.8606 | N/A |
| F-score Threshold | 0.538 | N/A |
| F-score | 0.9296 | N/A |