TargetNet
P06756
Integrin alpha-V
Function
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Database Links
| Database | Links |
|---|---|
| UniProt | P06756 |
| PDB | 1JV2, 1L5G, 1M1X, 1U8C, 3IJE, 4G1E, 4G1M |
| BioGrid | 109891 |
| BindingDB | P06756 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA37336 |
| KEGG | hsa:3685 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3685 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9894 | 6.1906 × 10-4 |
| Accuracy | 0.9595 | 0.002 |
| Sensitivity | 0.9616 | 0.0029 |
| Specificity | 0.9577 | 0.0022 |
| BEDROC | 0.9974 | 9.3926 × 10-4 |
| MCC Threshold | 0.488 | N/A |
| MCC | 0.9237 | N/A |
| F-score Threshold | 0.488 | N/A |
| F-score | 0.9601 | N/A |