TargetNet
P06737
Glycogen phosphorylase, liver form
Function
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Database Links
| Database | Links |
|---|---|
| UniProt | P06737 |
| PDB | 1EM6, 1EXV, 1FA9, 1FC0, 1L5Q, 1L5R, 1L5S, 1L7X, 1XOI, 2ATI, 2QLL, 2ZB2, 3CEH, 3CEJ, 3CEM, 3DD1, 3DDS, 3DDW |
| BioGrid | 111794 |
| BindingDB | P06737 |
| DrugBank | DB00131, DB00114, DB00140 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA34068 |
| KEGG | hsa:5836 |
| BioCyc | MetaCyc:HS02099-MONOMER |
| Entrez Gene (GeneID) | 5836 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9837 | 9.4172 × 10-4 |
| Accuracy | 0.9436 | 0.0043 |
| Sensitivity | 0.949 | 0.0052 |
| Specificity | 0.939 | 0.0066 |
| BEDROC | 0.9933 | 0.0028 |
| MCC Threshold | 0.552 | N/A |
| MCC | 0.904 | N/A |
| F-score Threshold | 0.552 | N/A |
| F-score | 0.948 | N/A |