TargetNet
P06401
Progesterone receptor
Function
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
Database Links
| Database | Links |
|---|---|
| UniProt | P06401 |
| PDB | 1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU |
| BioGrid | 111260 |
| BindingDB | P06401 |
| DrugBank | DB00304, DB01395, DB00378, DB00823, DB00294, DB00367, DB00603, DB00351, DB00834, DB00717, DB00957, DB00506, DB00396 |
| Guide to PHARMACOLOGY | 627 |
| PharmGKB | PA266 |
| KEGG | hsa:5241 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5241 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9898 | 6.7764 × 10-4 |
| Accuracy | 0.9643 | 0.0016 |
| Sensitivity | 0.9613 | 0.0035 |
| Specificity | 0.9672 | 0.0012 |
| BEDROC | 0.9983 | 9.8001 × 10-4 |
| MCC Threshold | 0.482 | N/A |
| MCC | 0.9271 | N/A |
| F-score Threshold | 0.468 | N/A |
| F-score | 0.963 | N/A |