TargetNet
P05362
Intercellular adhesion molecule 1
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Database Links
| Database | Links |
|---|---|
| UniProt | P05362 |
| PDB | 1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1IJ4, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX |
| BioGrid | 109610 |
| BindingDB | P05362 |
| DrugBank | DB00108, DB00641 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA29592 |
| KEGG | hsa:3383 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3383 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9571 | 0.003 |
| Accuracy | 0.8997 | 0.0044 |
| Sensitivity | 0.8991 | 0.0066 |
| Specificity | 0.9003 | 0.0059 |
| BEDROC | 0.9899 | 0.0078 |
| MCC Threshold | 0.548 | N/A |
| MCC | 0.8129 | N/A |
| F-score Threshold | 0.506 | N/A |
| F-score | 0.9099 | N/A |