Plasminogen activator inhibitor 1
Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
Database | Links |
---|---|
UniProt | P05121 |
PDB | 1A7C, 1B3K, 1C5G, 1DB2, 1DVM, 1DVN, 1LJ5, 1OC0, 3CVM, 3EOX, 3PB1, 3Q02, 3Q03, 3R4L, 3UT3, 4AQH, 4G8O, 4G8R, 4IC0, 9PAI |
BioGrid | 111091 |
BindingDB | P05121 |
DrugBank | DB01076, DB01093, DB00055, DB00641, DB00031, DB00197, DB00013 |
Guide to PHARMACOLOGY | Not available |
PharmGKB | PA261 |
KEGG | hsa:5054 |
BioCyc | Not available |
Entrez Gene (GeneID) | 5054 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.8594 | 0.0099 |
Accuracy | 0.8149 | 0.0182 |
Sensitivity | 0.8281 | 0.018 |
Specificity | 0.7993 | 0.0214 |
BEDROC | 0.9152 | 0.0369 |
MCC Threshold | 0.596 | N/A |
MCC | 0.6958 | N/A |
F-score Threshold | 0.552 | N/A |
F-score | 0.8469 | N/A |