TargetNet
P05106
Integrin beta-3
Function
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Database Links
| Database | Links |
|---|---|
| UniProt | P05106 |
| PDB | 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1RN0, 1S4X, 1TYE, 1U8C, 2INI, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDO, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M |
| BioGrid | 109896 |
| BindingDB | P05106 |
| DrugBank | DB00054, DB00775 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA205 |
| KEGG | hsa:3690 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3690 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9924 | 8.3777 × 10-4 |
| Accuracy | 0.9652 | 0.0023 |
| Sensitivity | 0.9702 | 0.0034 |
| Specificity | 0.9604 | 0.0035 |
| BEDROC | 0.999 | 3.2911 × 10-4 |
| MCC Threshold | 0.57 | N/A |
| MCC | 0.9371 | N/A |
| F-score Threshold | 0.57 | N/A |
| F-score | 0.9676 | N/A |