TargetNet
P05093
Steroid 17-alpha-hydroxylase/17,20 lyase
Function
Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Database Links
| Database | Links |
|---|---|
| UniProt | P05093 |
| PDB | 2C17, 3RUK, 3SWZ |
| BioGrid | 107958 |
| BindingDB | P05093 |
| DrugBank | DB00157, DB00396 |
| Guide to PHARMACOLOGY | 1361 |
| PharmGKB | PA27090 |
| KEGG | hsa:1586 |
| BioCyc | MetaCyc:HS07560-MONOMER |
| Entrez Gene (GeneID) | 1586 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9848 | 0.0036 |
| Accuracy | 0.9498 | 0.0049 |
| Sensitivity | 0.9696 | 0.0102 |
| Specificity | 0.9324 | 0.0059 |
| BEDROC | 0.9985 | 8.8867 × 10-4 |
| MCC Threshold | 0.484 | N/A |
| MCC | 0.9054 | N/A |
| F-score Threshold | 0.484 | N/A |
| F-score | 0.9501 | N/A |