TargetNet
P04818
Thymidylate synthase
Function
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Database Links
| Database | Links |
|---|---|
| UniProt | P04818 |
| PDB | 1HVY, 1HW3, 1HW4, 1HZW, 1I00, 1JU6, 1JUJ, 1YPV, 2ONB, 2RD8, 2RDA, 3EAW, 3EBU, 3ED7, 3EDW, 3EF9, 3EGY, 3EHI, 3EJL, 3GG5, 3GH0, 3GH2, 3H9K, 3HB8, 3N5E, 3N5G, 3OB7, 4E28, 4FGT, 4G2O, 4G6W, 4GD7, 4GYH, 4H1I |
| BioGrid | 113149 |
| BindingDB | P04818 |
| DrugBank | DB01101, DB00322, DB00544, DB00441, DB00650, DB00642, DB00293, DB00432 |
| Guide to PHARMACOLOGY | 2642 |
| PharmGKB | PA359 |
| KEGG | hsa:7298 |
| BioCyc | MetaCyc:HS11096-MONOMER |
| Entrez Gene (GeneID) | 7298 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9281 | 0.0039 |
| Accuracy | 0.8763 | 0.0027 |
| Sensitivity | 0.8588 | 0.0094 |
| Specificity | 0.8923 | 0.0058 |
| BEDROC | 0.9872 | 0.0025 |
| MCC Threshold | 0.542 | N/A |
| MCC | 0.7668 | N/A |
| F-score Threshold | 0.508 | N/A |
| F-score | 0.8769 | N/A |