TargetNet
P04150
Glucocorticoid receptor
Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.
Database Links
| Database | Links |
|---|---|
| UniProt | P04150 |
| PDB | 1M2Z, 1NHZ, 1P93, 3BQD, 3CLD, 3E7C, 3H52, 3K22, 3K23, 4HN5, 4HN6, 4LSJ |
| BioGrid | 109165 |
| BindingDB | P04150 |
| DrugBank | DB00288, DB00443, DB01222, DB01234, DB00663, DB00180, DB00588, DB00769, DB00741, DB00873, DB00959, DB00834, DB00764, DB00635 |
| Guide to PHARMACOLOGY | 625 |
| PharmGKB | PA181 |
| KEGG | hsa:2908 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2908 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9922 | 5.0553 × 10-4 |
| Accuracy | 0.9708 | 9.9758 × 10-4 |
| Sensitivity | 0.9678 | 0.0018 |
| Specificity | 0.9735 | 0.0017 |
| BEDROC | 0.9996 | 1.4382 × 10-4 |
| MCC Threshold | 0.446 | N/A |
| MCC | 0.943 | N/A |
| F-score Threshold | 0.446 | N/A |
| F-score | 0.9694 | N/A |