TargetNet
P04058
Acetylcholinesterase
Function
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
Database Links
| Database | Links |
|---|---|
| UniProt | P04058 |
| PDB | 1ACJ, 1ACL, 1AMN, 1AX9, 1CFJ, 1DX6, 1E3Q, 1E66, 1EA5, 1EEA, 1EVE, 1FSS, 1GPK, 1GPN, 1GQR, 1GQS, 1H22, 1H23, 1HBJ, 1JGA, 1JGB, 1JJB, 1OCE, 1ODC, 1QID, 1QIE, 1QIF, 1QIG, 1QIH, 1QII, 1QIJ, 1QIK, 1QIM, 1QTI, 1SOM, 1U65, 1UT6, 1VOT, 1VXO, 1VXR, 1W4L, 1W6R, 1W75, 1W76, 1ZGB, 1ZGC, 2ACE, 2ACK, 2BAG, 2C4H, 2C58, 2C5F, 2C5G, 2CEK, 2CKM, 2CMF, 2DFP, 2J3D, 2J3Q, 2J4F, 2V96, 2V97, 2V98, 2VA9, 2VJA, 2VJB, 2VJC, 2VJD, 2VQ6, 2VT6, 2VT7, 2W6C, 2W9I, 2WFZ, 2WG0, 2WG1, 2WG2, 2XI4, 3ACE, 3GEL, 3I6M, 3I6Z, 3M3D, 3ZV7, 4ACE |
| BioGrid | Not available |
| BindingDB | P04058 |
| DrugBank | DB00674 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | MetaCyc:MONOMER-16823 |
| Entrez Gene (GeneID) | Not available |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9012 | 0.0061 |
| Accuracy | 0.8431 | 0.0047 |
| Sensitivity | 0.8322 | 0.0095 |
| Specificity | 0.8546 | 0.0102 |
| BEDROC | 0.963 | 0.0275 |
| MCC Threshold | 0.53 | N/A |
| MCC | 0.7044 | N/A |
| F-score Threshold | 0.53 | N/A |
| F-score | 0.8522 | N/A |