TargetNet
P04054
Phospholipase A2
Function
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
Database Links
| Database | Links |
|---|---|
| UniProt | P04054 |
| PDB | 1YSK, 3ELO |
| BioGrid | 111336 |
| BindingDB | P04054 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA33361 |
| KEGG | hsa:5319 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5319 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.7638 | 0.0132 |
| Accuracy | 0.7 | 0.0118 |
| Sensitivity | 0.5404 | 0.0135 |
| Specificity | 0.8298 | 0.0144 |
| BEDROC | 0.9591 | 0.0051 |
| MCC Threshold | 0.6 | N/A |
| MCC | 0.4281 | N/A |
| F-score Threshold | 0.328 | N/A |
| F-score | 0.6872 | N/A |