TargetNet
P04035
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Function
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Database Links
| Database | Links |
|---|---|
| UniProt | P04035 |
| PDB | 1DQ8, 1DQ9, 1DQA, 1HW8, 1HW9, 1HWI, 1HWJ, 1HWK, 1HWL, 2Q1L, 2Q6B, 2Q6C, 2R4F, 3BGL, 3CCT, 3CCW, 3CCZ, 3CD0, 3CD5, 3CD7, 3CDA, 3CDB |
| BioGrid | 109399 |
| BindingDB | P04035 |
| DrugBank | DB01076, DB01393, DB00439, DB01095, DB00227, DB00157, DB00175, DB01098, DB00641 |
| Guide to PHARMACOLOGY | 639 |
| PharmGKB | PA189 |
| KEGG | hsa:3156 |
| BioCyc | MetaCyc:HS03652-MONOMER |
| Entrez Gene (GeneID) | 3156 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.98 | 0.0057 |
| Accuracy | 0.9285 | 0.0052 |
| Sensitivity | 0.9356 | 0.0101 |
| Specificity | 0.922 | 0.0088 |
| BEDROC | 0.9981 | 0.003 |
| MCC Threshold | 0.364 | N/A |
| MCC | 0.8666 | N/A |
| F-score Threshold | 0.364 | N/A |
| F-score | 0.9318 | N/A |