TargetNet
P03956
Interstitial collagenase
Function
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Database Links
| Database | Links |
|---|---|
| UniProt | P03956 |
| PDB | 1AYK, 1CGE, 1CGF, 1CGL, 1HFC, 1SU3, 2AYK, 2CLT, 2J0T, 2TCL, 3AYK, 3SHI, 4AUO, 4AYK, 966C |
| BioGrid | 110456 |
| BindingDB | P03956 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1628 |
| PharmGKB | PA30867 |
| KEGG | hsa:4312 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4312 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9701 | 9.1747 × 10-4 |
| Accuracy | 0.9235 | 0.0029 |
| Sensitivity | 0.9284 | 0.0042 |
| Specificity | 0.9188 | 0.004 |
| BEDROC | 0.9838 | 0.0041 |
| MCC Threshold | 0.44 | N/A |
| MCC | 0.8565 | N/A |
| F-score Threshold | 0.44 | N/A |
| F-score | 0.9276 | N/A |