TargetNet
P02550
Tubulin alpha-1A chain
Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Database Links
| Database | Links |
|---|---|
| UniProt | P02550 |
| PDB | 1FFX, 1IA0, 1TUB, 2HXF, 2HXH, 2P4N, 2WBE, 4ABO |
| BioGrid | Not available |
| BindingDB | P02550 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | Not available |
| Entrez Gene (GeneID) | Not available |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8394 | 0.0087 |
| Accuracy | 0.7482 | 0.0115 |
| Sensitivity | 0.786 | 0.0137 |
| Specificity | 0.701 | 0.0168 |
| BEDROC | 0.9428 | 0.0358 |
| MCC Threshold | 0.636 | N/A |
| MCC | 0.52 | N/A |
| F-score Threshold | 0.39 | N/A |
| F-score | 0.8 | N/A |