TargetNet
P01375
Tumor necrosis factor
Function
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Database Links
| Database | Links |
|---|---|
| UniProt | P01375 |
| PDB | 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 5TSW |
| BioGrid | 112979 |
| BindingDB | P01375 |
| DrugBank | DB00051, DB00640, DB01427, DB01076, DB00608, DB01407, DB00005, DB01296, DB00065, DB00704, DB01411, DB01366, DB01232, DB00641, DB01041 |
| Guide to PHARMACOLOGY | 2635 |
| PharmGKB | PA435 |
| KEGG | hsa:7124 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 7124 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8215 | 0.0045 |
| Accuracy | 0.7226 | 0.005 |
| Sensitivity | 0.5858 | 0.0097 |
| Specificity | 0.8534 | 0.008 |
| BEDROC | 0.9789 | 0.0047 |
| MCC Threshold | 0.68 | N/A |
| MCC | 0.5116 | N/A |
| F-score Threshold | 0.398 | N/A |
| F-score | 0.7515 | N/A |