TargetNet
P00915
Carbonic anhydrase 1
Function
Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.
Database Links
| Database | Links |
|---|---|
| UniProt | P00915 |
| PDB | 1AZM, 1BZM, 1CRM, 1CZM, 1HCB, 1HUG, 1HUH, 1J9W, 1JV0, 2CAB, 2FOY, 2FW4, 2IT4, 2NMX, 2NN1, 2NN7, 3LXE, 3W6H, 3W6I |
| BioGrid | 107214 |
| BindingDB | P00915 |
| DrugBank | DB00819, DB00381, DB00436, DB00562, DB01194, DB00880, DB00606, DB01119, DB01144, DB01031, DB00311, DB00999, DB00774, DB01202, DB00703, DB00232, DB01325, DB01021, DB00661, DB00909 |
| Guide to PHARMACOLOGY | 2597 |
| PharmGKB | PA25984 |
| KEGG | hsa:759 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 759 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9478 | 0.0012 |
| Accuracy | 0.8865 | 0.0031 |
| Sensitivity | 0.8946 | 0.0049 |
| Specificity | 0.8781 | 0.0028 |
| BEDROC | 0.9707 | 0.0052 |
| MCC Threshold | 0.398 | N/A |
| MCC | 0.7774 | N/A |
| F-score Threshold | 0.372 | N/A |
| F-score | 0.8935 | N/A |