TargetNet
P00797
Renin
Function
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Database Links
| Database | Links |
|---|---|
| UniProt | P00797 |
| PDB | 1BBS, 1BIL, 1BIM, 1HRN, 1RNE, 2BKS, 2BKT, 2FS4, 2G1N, 2G1O, 2G1R, 2G1S, 2G1Y, 2G20, 2G21, 2G22, 2G24, 2G26, 2G27, 2I4Q, 2IKO, 2IKU, 2IL2, 2REN, 2V0Z, 2V10, 2V11, 2V12, 2V13, 2V16, 2X0B, 3D91, 3G6Z, 3G70, 3G72, 3GW5, 3K1W, 3KM4, 3O9L, 3OAD, 3OAG, 3OOT, 3OQF, 3OQK, 3OWN, 3Q3T, 3Q4B, 3Q5H, 3SFC, 3VCM, 3VSW, 3VSX, 3VUC, 3VYD, 3VYE, 3VYF, 4AMT, 4GJ5, 4GJ6, 4GJ7, 4GJ8, 4GJ9, 4GJA, 4GJB, 4GJC, 4GJD |
| BioGrid | 111904 |
| BindingDB | P00797 |
| DrugBank | DB01258, DB00212 |
| Guide to PHARMACOLOGY | 2413 |
| PharmGKB | PA297 |
| KEGG | hsa:5972 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5972 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9872 | 5.7418 × 10-4 |
| Accuracy | 0.9585 | 0.0012 |
| Sensitivity | 0.9759 | 0.0014 |
| Specificity | 0.9387 | 0.0016 |
| BEDROC | 0.9978 | 0.0013 |
| MCC Threshold | 0.488 | N/A |
| MCC | 0.9201 | N/A |
| F-score Threshold | 0.488 | N/A |
| F-score | 0.9631 | N/A |