TargetNet
P00750
Tissue-type plasminogen activator
Function
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Database Links
| Database | Links |
|---|---|
| UniProt | P00750 |
| PDB | 1A5H, 1BDA, 1PK2, 1PML, 1RTF, 1TPG, 1TPK, 1TPM, 1TPN |
| BioGrid | 111343 |
| BindingDB | P00750 |
| DrugBank | DB00009, DB00513, DB00029, DB01088, DB00015, DB00031, DB00302, DB00013 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA33381 |
| KEGG | hsa:5327 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5327 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.924 | 0.0067 |
| Accuracy | 0.8603 | 0.0089 |
| Sensitivity | 0.8679 | 0.0149 |
| Specificity | 0.8538 | 0.0112 |
| BEDROC | 0.9439 | 0.0098 |
| MCC Threshold | 0.474 | N/A |
| MCC | 0.7505 | N/A |
| F-score Threshold | 0.474 | N/A |
| F-score | 0.8678 | N/A |