P00749

Urokinase-type plasminogen activator

Function

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

Database Links

Database	Links
UniProt	P00749
PDB	1C5W, 1C5X, 1C5Y, 1C5Z, 1EJN, 1F5K, 1F5L, 1F92, 1FV9, 1GI7, 1GI8, 1GI9, 1GJ7, 1GJ8, 1GJ9, 1GJA, 1GJB, 1GJC, 1GJD, 1KDU, 1LMW, 1O3P, 1O5A, 1O5B, 1O5C, 1OWD, 1OWE, 1OWH, 1OWI, 1OWJ, 1OWK, 1SC8, 1SQA, 1SQO, 1SQT, 1U6Q, 1URK, 1VJ9, 1VJA, 1W0Z, 1W10, 1W11, 1W12, 1W13, 1W14, 2FD6, 2I9A, 2I9B, 2NWN, 2O8T, 2O8U, 2O8W, 2R2W, 2VIN, 2VIO, 2VIP, 2VIQ, 2VIV, 2VIW, 2VNT, 3BT1, 3BT2, 3IG6, 3KGP, 3KHV, 3KID, 3M61, 3MHW, 3MWI, 3OX7, 3OY5, 3OY6, 3PB1, 3QN7, 3U73, 4DVA, 4DW2, 4FU7, 4FU8, 4FU9, 4FUB, 4FUC, 4FUD, 4FUE, 4FUF, 4FUG, 4FUH, 4FUI, 4FUJ, 4GLY, 4H42, 4JK5, 4JK6
BioGrid	111344
BindingDB	P00749
DrugBank	DB00594, DB00013
Guide to PHARMACOLOGY	2393
PharmGKB	PA33382
KEGG	hsa:5328
BioCyc	Not available
Entrez Gene (GeneID)	5328

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.9297	0.0023
Accuracy	0.8671	0.0049
Sensitivity	0.8624	0.0073
Specificity	0.8719	0.005
BEDROC	0.9695	0.0024
MCC Threshold	0.456	N/A
MCC	0.7448	N/A
F-score Threshold	0.456	N/A
F-score	0.8747	N/A

Downloads

R Model Object

Random Forest model object (.RData)

Positive Set

SMILES string + affinity value (.tsv)