TargetNet
P00747
Plasminogen
Function
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Database Links
| Database | Links |
|---|---|
| UniProt | P00747 |
| PDB | 1B2I, 1BML, 1BUI, 1CEA, 1CEB, 1DDJ, 1HPJ, 1HPK, 1I5K, 1KI0, 1KRN, 1L4D, 1L4Z, 1PK4, 1PKR, 1PMK, 1QRZ, 1RJX, 2DOH, 2DOI, 2KNF, 2L0S, 2PK4, 3UIR, 4A5T, 4DCB, 4DUR, 4DUU, 5HPG |
| BioGrid | 111356 |
| BindingDB | P00747 |
| DrugBank | DB00513, DB00086, DB00302, DB00013 |
| Guide to PHARMACOLOGY | 2394 |
| PharmGKB | PA33405 |
| KEGG | hsa:5340 |
| BioCyc | MetaCyc:HS04553-MONOMER |
| Entrez Gene (GeneID) | 5340 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9236 | 0.0018 |
| Accuracy | 0.8457 | 0.0057 |
| Sensitivity | 0.8422 | 0.0071 |
| Specificity | 0.8492 | 0.0062 |
| BEDROC | 0.9563 | 0.0079 |
| MCC Threshold | 0.414 | N/A |
| MCC | 0.6985 | N/A |
| F-score Threshold | 0.378 | N/A |
| F-score | 0.8511 | N/A |