P00742

Coagulation factor X

Function

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Database Links

Database	Links
UniProt	P00742
PDB	1C5M, 1EZQ, 1F0R, 1F0S, 1FAX, 1FJS, 1FXY, 1G2L, 1G2M, 1HCG, 1IOE, 1IQE, 1IQF, 1IQG, 1IQH, 1IQI, 1IQJ, 1IQK, 1IQL, 1IQM, 1IQN, 1KSN, 1LPG, 1LPK, 1LPZ, 1LQD, 1MQ5, 1MQ6, 1MSX, 1NFU, 1NFW, 1NFX, 1NFY, 1NL8, 1P0S, 1V3X, 1WU1, 1XKA, 1XKB, 1Z6E, 2BMG, 2BOH, 2BOK, 2BQ6, 2BQ7, 2BQW, 2CJI, 2D1J, 2EI6, 2EI7, 2EI8, 2FZZ, 2G00, 2GD4, 2H9E, 2J2U, 2J34, 2J38, 2J4I, 2J94, 2J95, 2JKH, 2P16, 2P3F, 2P3T, 2P3U, 2P93, 2P94, 2P95, 2PHB, 2PR3, 2Q1J, 2RA0, 2UWL, 2UWO, 2UWP, 2VH0, 2VH6, 2VVC, 2VVU, 2VVV, 2VWL, 2VWM, 2VWN, 2VWO, 2W26, 2W3I, 2W3K, 2WYG, 2WYJ, 2XBV, 2XBW, 2XBX, 2XBY, 2XC0, 2XC4, 2XC5, 2Y5F, 2Y5G, 2Y5H, 2Y7X, 2Y7Z, 2Y80, 2Y81, 2Y82, 3CEN, 3CS7, 3ENS, 3FFG, 3HPT, 3IIT, 3K9X, 3KL6, 3KQB, 3KQC, 3KQD, 3KQE, 3LIW, 3M36, 3M37, 3Q3K, 3SW2, 3TK5, 3TK6, 4A7I, 4BTI, 4BTT, 4BTU
BioGrid	108457
BindingDB	P00742
DrugBank	DB00009, DB00029, DB00025, DB00100, DB00036, DB01225, DB01109, DB00170, DB00015, DB00031
Guide to PHARMACOLOGY	2359
PharmGKB	PA27940
KEGG	hsa:2159
BioCyc	MetaCyc:HS05000-MONOMER
Entrez Gene (GeneID)	2159

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.9872	4.5347 × 10^-4
Accuracy	0.9551	0.0015
Sensitivity	0.9674	0.0019
Specificity	0.9414	0.0024
BEDROC	0.9985	7.861 × 10^-4
MCC Threshold	0.43	N/A
MCC	0.9169	N/A
F-score Threshold	0.43	N/A
F-score	0.961	N/A

Downloads

R Model Object

Random Forest model object (.RData)

Download RData

Positive Set

SMILES string + affinity value (.tsv)

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TargetNet