TargetNet
P00735
Prothrombin
Function
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P00735 |
| PDB | 1A0H, 1AVG, 1BBR, 1ETR, 1ETS, 1ETT, 1HRT, 1ID5, 1MKW, 1MKX, 1NL1, 1NL2, 1TBQ, 1TBR, 1TOC, 1UCY, 1UVT, 1UVU, 1VIT, 1YCP, 2A1D, 2HPP, 2ODY, 2PF1, 2PF2, 2SPT, 3PMA, 3PMB |
| BioGrid | Not available |
| BindingDB | P00735 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | bta:280685 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 280685 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9166 | 0.0073 |
| Accuracy | 0.8863 | 0.0068 |
| Sensitivity | 0.8261 | 0.0096 |
| Specificity | 0.9427 | 0.0087 |
| BEDROC | 0.9956 | 0.0014 |
| MCC Threshold | 0.378 | N/A |
| MCC | 0.7994 | N/A |
| F-score Threshold | 0.378 | N/A |
| F-score | 0.8929 | N/A |