TargetNet
P00491
Purine nucleoside phosphorylase
Function
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
Database Links
| Database | Links |
|---|---|
| UniProt | P00491 |
| PDB | 1M73, 1PF7, 1PWY, 1RCT, 1RFG, 1RR6, 1RSZ, 1RT9, 1ULA, 1ULB, 1V2H, 1V3Q, 1V41, 1V45, 1YRY, 2A0W, 2A0X, 2A0Y, 2OC4, 2OC9, 2ON6, 2Q7O, 3BGS, 3D1V, 3GB9, 3GGS, 3INY, 3K8O, 3K8Q, 3PHB, 4EAR, 4EB8, 4ECE, 4GKA |
| BioGrid | 110921 |
| BindingDB | P00491 |
| DrugBank | DB00787, DB00242, DB01033 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA31694 |
| KEGG | hsa:4860 |
| BioCyc | MetaCyc:HS02151-MONOMER |
| Entrez Gene (GeneID) | 4860 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9793 | 0.0026 |
| Accuracy | 0.9321 | 0.0054 |
| Sensitivity | 0.95 | 0.0076 |
| Specificity | 0.9153 | 0.01 |
| BEDROC | 0.9941 | 0.0023 |
| MCC Threshold | 0.518 | N/A |
| MCC | 0.8618 | N/A |
| F-score Threshold | 0.518 | N/A |
| F-score | 0.9291 | N/A |