Dihydrofolate reductase
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.
Database | Links |
---|---|
UniProt | P00375 |
PDB | 1U70, 2FZJ, 3D80, 3D84, 3K45, 3K47 |
BioGrid | Not available |
BindingDB | P00375 |
DrugBank | Not available |
Guide to PHARMACOLOGY | Not available |
PharmGKB | Not available |
KEGG | mmu:13361 |
BioCyc | Not available |
Entrez Gene (GeneID) | 13361 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9852 | 0.0014 |
Accuracy | 0.9518 | 0.0064 |
Sensitivity | 0.957 | 0.0129 |
Specificity | 0.9465 | 0.0116 |
BEDROC | 0.9996 | 4.7646 × 10-4 |
MCC Threshold | 0.512 | N/A |
MCC | 0.9217 | N/A |
F-score Threshold | 0.512 | N/A |
F-score | 0.9612 | N/A |