TargetNet
P00374
Dihydrofolate reductase
Function
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.
Database Links
| Database | Links |
|---|---|
| UniProt | P00374 |
| PDB | 1BOZ, 1DHF, 1DLR, 1DLS, 1DRF, 1HFP, 1HFQ, 1HFR, 1KMS, 1KMV, 1MVS, 1MVT, 1OHJ, 1OHK, 1PD8, 1PD9, 1PDB, 1S3U, 1S3V, 1S3W, 1U71, 1U72, 1YHO, 2C2S, 2C2T, 2DHF, 2W3A, 2W3B, 2W3M, 3EIG, 3F8Y, 3F8Z, 3F91, 3FS6, 3GHC, 3GHV, 3GHW, 3GI2, 3GYF, 3L3R, 3N0H, 3NTZ, 3NU0, 3NXO, 3NXR, 3NXT, 3NXV, 3NXX, 3NXY, 3NZD, 3OAF, 3S3V, 3S7A, 4DDR, 4G95, 4KAK, 4KBN, 4KD7, 4KEB, 4KFJ, 4M6J, 4M6K, 4M6L |
| BioGrid | 108065 |
| BindingDB | P00374 |
| DrugBank | DB00250, DB01093, DB00555, DB00563, DB00157, DB00642, DB01131, DB00205, DB00440, DB01157 |
| Guide to PHARMACOLOGY | 2603 |
| PharmGKB | PA143 |
| KEGG | hsa:1719 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1719 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9555 | 0.0022 |
| Accuracy | 0.9036 | 0.0036 |
| Sensitivity | 0.8968 | 0.0069 |
| Specificity | 0.9095 | 0.0038 |
| BEDROC | 0.9842 | 0.005 |
| MCC Threshold | 0.502 | N/A |
| MCC | 0.8164 | N/A |
| F-score Threshold | 0.502 | N/A |
| F-score | 0.9014 | N/A |