TargetNet
O95977
Sphingosine 1-phosphate receptor 4
Function
Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
Database Links
| Database | Links |
|---|---|
| UniProt | O95977 |
| PDB | 2DCO |
| BioGrid | 114243 |
| BindingDB | O95977 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 278 |
| PharmGKB | PA162402371 |
| KEGG | hsa:8698 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 8698 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.947 | 0.0038 |
| Accuracy | 0.9036 | 0.0044 |
| Sensitivity | 0.8602 | 0.009 |
| Specificity | 0.9417 | 0.0045 |
| BEDROC | 0.9914 | 0.0043 |
| MCC Threshold | 0.53 | N/A |
| MCC | 0.8272 | N/A |
| F-score Threshold | 0.53 | N/A |
| F-score | 0.9031 | N/A |