TargetNet
O95136
Sphingosine 1-phosphate receptor 2
Function
Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Database Links
| Database | Links |
|---|---|
| UniProt | O95136 |
| PDB | 1ZTI |
| BioGrid | Not available |
| BindingDB | O95136 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 276 |
| PharmGKB | PA162402353 |
| KEGG | hsa:9294 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 9294 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9145 | 0.0044 |
| Accuracy | 0.8121 | 0.0075 |
| Sensitivity | 0.808 | 0.0215 |
| Specificity | 0.8157 | 0.0176 |
| BEDROC | 0.9916 | 0.0056 |
| MCC Threshold | 0.482 | N/A |
| MCC | 0.6644 | N/A |
| F-score Threshold | 0.448 | N/A |
| F-score | 0.8283 | N/A |