Disintegrin and metalloproteinase domain-containing protein 17
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell- surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor- alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (By similarity).
Database | Links |
---|---|
UniProt | O77636 |
PDB | Not available |
BioGrid | Not available |
BindingDB | O77636 |
DrugBank | Not available |
Guide to PHARMACOLOGY | Not available |
PharmGKB | Not available |
KEGG | Not available |
BioCyc | Not available |
Entrez Gene (GeneID) | Not available |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9957 | 0.0012 |
Accuracy | 0.9694 | 0.004 |
Sensitivity | 0.981 | 0.0045 |
Specificity | 0.9581 | 0.0048 |
BEDROC | 0.9999 | 3.9843 × 10-5 |
MCC Threshold | 0.51 | N/A |
MCC | 0.9567 | N/A |
F-score Threshold | 0.51 | N/A |
F-score | 0.9783 | N/A |