TargetNet
O77636
Disintegrin and metalloproteinase domain-containing protein 17
Function
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell- surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor- alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | O77636 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | O77636 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | Not available |
| Entrez Gene (GeneID) | Not available |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9957 | 0.0012 |
| Accuracy | 0.9694 | 0.004 |
| Sensitivity | 0.981 | 0.0045 |
| Specificity | 0.9581 | 0.0048 |
| BEDROC | 0.9999 | 3.9843 × 10-5 |
| MCC Threshold | 0.51 | N/A |
| MCC | 0.9567 | N/A |
| F-score Threshold | 0.51 | N/A |
| F-score | 0.9783 | N/A |