TargetNet
O60240
Perilipin-1
Function
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.
Database Links
| Database | Links |
|---|---|
| UniProt | O60240 |
| PDB | Not available |
| BioGrid | 111361 |
| BindingDB | O60240 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA33409 |
| KEGG | hsa:5346 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5346 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8482 | 0.0048 |
| Accuracy | 0.772 | 0.0075 |
| Sensitivity | 0.7696 | 0.0167 |
| Specificity | 0.775 | 0.0134 |
| BEDROC | 0.9845 | 0.0193 |
| MCC Threshold | 0.578 | N/A |
| MCC | 0.5778 | N/A |
| F-score Threshold | 0.426 | N/A |
| F-score | 0.8057 | N/A |