TargetNet
O43613
Orexin receptor type 1
Function
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | O43613 |
| PDB | Not available |
| BioGrid | 109311 |
| BindingDB | O43613 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 321 |
| PharmGKB | PA29222 |
| KEGG | hsa:3061 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3061 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8811 | 0.0042 |
| Accuracy | 0.8016 | 0.0082 |
| Sensitivity | 0.7703 | 0.0125 |
| Specificity | 0.8403 | 0.0114 |
| BEDROC | 0.9765 | 0.0064 |
| MCC Threshold | 0.594 | N/A |
| MCC | 0.6516 | N/A |
| F-score Threshold | 0.428 | N/A |
| F-score | 0.8168 | N/A |