TargetNet
O42713
Polyphenol oxidase 2
Function
Copper-containing oxidase that catalyzes both the o- hydroxylation of monophenols and the subsequent oxidation of the resulting o-diphenols into reactive o-quinones, which evolve spontaneously to produce intermediates, which associate in dark brown pigments. Involved in the initial step of melanin synthesis. Melanins constitute a mechanism of defense and resistance to stress such as UV radiations, free radicals, gamma rays, dehydratation and extreme temperatures, and contribute to the fungal cell-wall resistance against hydrolytic enzymes in avoiding cellular lysis. Fungal pigments are also involved in the formation and stability of spores (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | O42713 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | O42713 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | Not available |
| Entrez Gene (GeneID) | Not available |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8509 | 0.0122 |
| Accuracy | 0.7664 | 0.0213 |
| Sensitivity | 0.8133 | 0.0336 |
| Specificity | 0.7188 | 0.0213 |
| BEDROC | 0.8622 | 0.0353 |
| MCC Threshold | 0.758 | N/A |
| MCC | 0.551 | N/A |
| F-score Threshold | 0.344 | N/A |
| F-score | 0.7937 | N/A |