TargetNet
O14842
Free fatty acid receptor 1
Function
Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G- proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.
Database Links
| Database | Links |
|---|---|
| UniProt | O14842 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | O14842 |
| DrugBank | DB00159 |
| Guide to PHARMACOLOGY | 225 |
| PharmGKB | PA28887 |
| KEGG | hsa:2864 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2864 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9701 | 0.0029 |
| Accuracy | 0.9345 | 0.0021 |
| Sensitivity | 0.9571 | 0.0035 |
| Specificity | 0.9086 | 0.0052 |
| BEDROC | 0.9905 | 0.0066 |
| MCC Threshold | 0.64 | N/A |
| MCC | 0.8806 | N/A |
| F-score Threshold | 0.64 | N/A |
| F-score | 0.9447 | N/A |